[HTML][HTML] Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor
A Ikemoto, M Ohishi, Y Sato, N Hata, Y Misawa… - Journal of lipid …, 2001 - ASBMB
Rats fed a semipurified diet supplemented with 3%(w/w) safflower oil [Saf, n-3 fatty acid
deficient, high linoleic acid (18: 2n-6)] through two generations exhibit decreased correct
response ratios in a brightness-discrimination learning test compared with rats fed 3%
perilla oil [Per, high α-linolenic acid (18: 3n-3)]. This is associated with a decreased DHA
(22: 6n-3)-to-arachidonic acid (20: 4n-6) ratio in brain lipids. In the first set of experiments,
dietary oil was shifted from Saf to a mixture of 2.4% safflower oil plus 0.6% DHA after …
deficient, high linoleic acid (18: 2n-6)] through two generations exhibit decreased correct
response ratios in a brightness-discrimination learning test compared with rats fed 3%
perilla oil [Per, high α-linolenic acid (18: 3n-3)]. This is associated with a decreased DHA
(22: 6n-3)-to-arachidonic acid (20: 4n-6) ratio in brain lipids. In the first set of experiments,
dietary oil was shifted from Saf to a mixture of 2.4% safflower oil plus 0.6% DHA after …