[HTML][HTML] Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
X Zhang, P Shan, D Jiang, PW Noble… - Journal of Biological …, 2004 - ASBMB
Heme oxygenase-1 (HO-1) is emerging as an important cytoprotective enzyme system in a
variety of injury models. To optimize future therapeutic applications of HO-1, it is necessary
to delineate the precise functions and mechanisms as well as modes of externally regulating
HO-1 expression. Investigations have been limited by difficulties with the generation of HO-1
null mice and the lack of specific HO-1 inhibitors. Lung ischemia-reperfusion (IR) injury is the
inciting event in acute lung failure following transplantation, surgery, and shock. To study the …
variety of injury models. To optimize future therapeutic applications of HO-1, it is necessary
to delineate the precise functions and mechanisms as well as modes of externally regulating
HO-1 expression. Investigations have been limited by difficulties with the generation of HO-1
null mice and the lack of specific HO-1 inhibitors. Lung ischemia-reperfusion (IR) injury is the
inciting event in acute lung failure following transplantation, surgery, and shock. To study the …