The human thymic microenvironment: thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation
AJ Laster, T Itoh, TJ Palker, BF Haynes - Differentiation, 1986 - Elsevier
Normal T-cell development is dependent on interactions with the thymic microenvironment;
thymic epithelial cells are thought to play a key role in the induction of thymocyte maturation,
both through direct contact and, indirectly, via thymic hormone secretion. It has been
postulated that thymic epithelial cells progress through an antigenically defined pathway of
differentiation similar to that of epidermal keratinocytes. As keratins vary according to
epithelial cell type and the stage of epithelial cell maturation, we used a panel of monoclonal …
thymic epithelial cells are thought to play a key role in the induction of thymocyte maturation,
both through direct contact and, indirectly, via thymic hormone secretion. It has been
postulated that thymic epithelial cells progress through an antigenically defined pathway of
differentiation similar to that of epidermal keratinocytes. As keratins vary according to
epithelial cell type and the stage of epithelial cell maturation, we used a panel of monoclonal …
