Silastic implants for delivering physiological concentrations of progesterone to mice
SR Milligan, PE Cohen - Reproduction, fertility and development, 1994 - CSIRO Publishing
SR Milligan, PE Cohen
Reproduction, fertility and development, 1994•CSIRO PublishingSilastic implants filled with progesterone in arachis oil were designed to provide a
convenient and reliable method for the delivery of physiological concentrations of
progesterone to mice. Placement of the implants in ovariectomized mice resulted in a rapid
increase in circulating progesterone within 6 h; stable levels could be maintained for many
days. Removal of the implants resulted in a very rapid fall in progesterone concentrations.
The delivery of progesterone from the implants could be controlled by varying both the …
convenient and reliable method for the delivery of physiological concentrations of
progesterone to mice. Placement of the implants in ovariectomized mice resulted in a rapid
increase in circulating progesterone within 6 h; stable levels could be maintained for many
days. Removal of the implants resulted in a very rapid fall in progesterone concentrations.
The delivery of progesterone from the implants could be controlled by varying both the …
Silastic implants filled with progesterone in arachis oil were designed to provide a convenient and reliable method for the delivery of physiological concentrations of progesterone to mice. Placement of the implants in ovariectomized mice resulted in a rapid increase in circulating progesterone within 6 h; stable levels could be maintained for many days. Removal of the implants resulted in a very rapid fall in progesterone concentrations. The delivery of progesterone from the implants could be controlled by varying both the length of the implants and the concentration of progesterone internally. This allowed plasma progesterone concentrations to be maintained and controlled over the entire physiological range.
CSIRO Publishing