[HTML][HTML] Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase
JY Yi, I Shin, CL Arteaga - Journal of Biological Chemistry, 2005 - ASBMB
We have examined the interaction of transforming growth factor (TGF) β receptors with
phosphatidylinositol 3-(PI3) kinase in epithelial cells. In COS7 cells, treatment with TGFβ
increased PI3 kinase activity as measured by the ability of p85-associated immune
complexes to phosphorylate inositides in vitro. Both type I and type II TGFβ receptors (TβR)
associated with p85, but the association of TβRII appeared to be constitutive. The interaction
of TβRI with p85 was induced by treatment with TGFβ. The receptor association with PI3 …
phosphatidylinositol 3-(PI3) kinase in epithelial cells. In COS7 cells, treatment with TGFβ
increased PI3 kinase activity as measured by the ability of p85-associated immune
complexes to phosphorylate inositides in vitro. Both type I and type II TGFβ receptors (TβR)
associated with p85, but the association of TβRII appeared to be constitutive. The interaction
of TβRI with p85 was induced by treatment with TGFβ. The receptor association with PI3 …