[HTML][HTML] Transforming growth factor-β1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities
Y Huang, D Hutter, Y Liu, X Wang, MS Sheikh… - Journal of Biological …, 2000 - ASBMB
Transforming growth factor (TGF)-β1, a pleiotropic cytokine involved in regulating growth
and differentiation, can exert both pro-apoptotic and anti-apoptotic effects depending on the
cell type or circumstances. We observed that TGF-β1 blocked apoptosis resulting from
serum withdrawal in A549 human lung carcinoma cells. This was associated with
suppression of JNK activation that occurs concomitant with the onset of apoptosis in the
absence of TGF-β1, suggesting that JNK plays an active role in the death process and that …
and differentiation, can exert both pro-apoptotic and anti-apoptotic effects depending on the
cell type or circumstances. We observed that TGF-β1 blocked apoptosis resulting from
serum withdrawal in A549 human lung carcinoma cells. This was associated with
suppression of JNK activation that occurs concomitant with the onset of apoptosis in the
absence of TGF-β1, suggesting that JNK plays an active role in the death process and that …