Regulation of the cyclooxygenase-2 system by interleukin-1β through mitogen-activated protein kinase signaling pathways: a comparative study of human …
AS Moolwaney, OJ Igwe - Molecular brain research, 2005 - Elsevier
Glial activation and inflammation following brain injury may initiate and maintain the process
of neurodegeneration. Both glia and neurons synthesize proinflammatory mediators such as
interleukin 1 beta (IL-1β), cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2),
and prostaglandins. The molecular mechanisms by which IL-1β regulates inflammatory
genes such as cPLA2 and COX-2 in glial and neuronal cells are poorly understood. We
have studied IL-1β-mediated gene regulation in an established glial and neuronal human …
of neurodegeneration. Both glia and neurons synthesize proinflammatory mediators such as
interleukin 1 beta (IL-1β), cytosolic phospholipase A2 (cPLA2), cyclooxygenase-2 (COX-2),
and prostaglandins. The molecular mechanisms by which IL-1β regulates inflammatory
genes such as cPLA2 and COX-2 in glial and neuronal cells are poorly understood. We
have studied IL-1β-mediated gene regulation in an established glial and neuronal human …
