Nuclear factor of activated T cells regulates transcription of the surfactant protein D gene (Sftpd) via direct interaction with thyroid transcription factor-1 in lung epithelial …
V Davé, T Childs, JA Whitsett - Journal of Biological Chemistry, 2004 - ASBMB
Surfactant protein D (SP-D) plays critical roles in host defense, surfactant homeostasis, and
pulmonary immunomodulation. Here, we identify a role of nuclear factor of activated T cells
(NFATs) in regulation of murine SP-D gene (Sftpd) transcription. An NFAT-dependent
enhancer modulated by NFATs or calcineurin and sensitive to cyclosporin was identified in
the Sftpd promoter. Ionomycin and phorbol 12-myristate 13-acetate further increased the
activity of this enhancer, whereas VIVIT, a potent NFAT inhibitor peptide, selectively …
pulmonary immunomodulation. Here, we identify a role of nuclear factor of activated T cells
(NFATs) in regulation of murine SP-D gene (Sftpd) transcription. An NFAT-dependent
enhancer modulated by NFATs or calcineurin and sensitive to cyclosporin was identified in
the Sftpd promoter. Ionomycin and phorbol 12-myristate 13-acetate further increased the
activity of this enhancer, whereas VIVIT, a potent NFAT inhibitor peptide, selectively …
