[HTML][HTML] Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor α from murine macrophages
B Gao, MF Tsan - Journal of Biological Chemistry, 2003 - ASBMB
Recent studies have shown that commercially available recombinant human heat shock
protein 60 (rhHSP60) could induce tumor necrosis factor α (TNF-α) release from
macrophages and monocytes in a manner similar to that of lipopolysaccharide (LPS), eg via
CD14 and Toll-like receptor 4 complex-mediated signal transduction pathway. In this study,
we demonstrated that a highly purified rhHSP60 preparation with low endotoxin activity
(designated rhHSP60-1) was unable to induce TNF-α release from murine macrophages at …
protein 60 (rhHSP60) could induce tumor necrosis factor α (TNF-α) release from
macrophages and monocytes in a manner similar to that of lipopolysaccharide (LPS), eg via
CD14 and Toll-like receptor 4 complex-mediated signal transduction pathway. In this study,
we demonstrated that a highly purified rhHSP60 preparation with low endotoxin activity
(designated rhHSP60-1) was unable to induce TNF-α release from murine macrophages at …