[HTML][HTML] Nitric oxide protects the skeletal muscle Ca2+ release channel from oxidation induced activation
B Aghdasi, MB Reid, SL Hamilton - Journal of Biological Chemistry, 1997 - ASBMB
Reactive oxygen intermediates and nitric oxide modulate the contractile function of skeletal
muscle fibers, possibly via direct interaction with the Ca 2+ release channel. Oxidants
produce disulfide bonds between subunits of the Ca 2+ release channel tetramer, and this is
accompanied by an increase in channel activity. The sulfhydryl alkylating agent N-
ethylmaleimide has three distinct effects on Ca 2+ release channel activity: first, channel
activity is decreased (phase 1); then with continued exposure the activity is dramatically …
muscle fibers, possibly via direct interaction with the Ca 2+ release channel. Oxidants
produce disulfide bonds between subunits of the Ca 2+ release channel tetramer, and this is
accompanied by an increase in channel activity. The sulfhydryl alkylating agent N-
ethylmaleimide has three distinct effects on Ca 2+ release channel activity: first, channel
activity is decreased (phase 1); then with continued exposure the activity is dramatically …
