[HTML][HTML] FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes
The skeletal muscle sarcoplasmic reticulum (SR) Ca 2+ release channel or ryanodine
receptor (RyR1) binds four molecules of FKBP12, and the interaction of FKBP12 with RyR1
regulates both unitary and coupled gating of the channel. We have characterized the
physiologic effects of previously identified mutations in RyR1 that disrupt FKBP12 binding
(V2461G and V2461I) on excitation-contraction (EC) coupling and intracellular Ca 2+
homeostasis following their expression in skeletal myotubes derived from RyR1-knockout …
receptor (RyR1) binds four molecules of FKBP12, and the interaction of FKBP12 with RyR1
regulates both unitary and coupled gating of the channel. We have characterized the
physiologic effects of previously identified mutations in RyR1 that disrupt FKBP12 binding
(V2461G and V2461I) on excitation-contraction (EC) coupling and intracellular Ca 2+
homeostasis following their expression in skeletal myotubes derived from RyR1-knockout …
