[HTML][HTML] Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO
Inhibitors of apoptosis (IAPs) are crucial regulators of programmed cell death. The
mechanism by which IAPs prevent apoptosis has previously been attributed to the direct
inhibition of caspases. The function of mammalian IAPs is counteracted by cell death
inducer second mitochondria-derived activator of caspases (Smac)/DIABLO during
apoptosis. Here we show that cIAP1 and cIAP2 are E3 ubiquitin-protein isopeptide ligases
(ubiquitin ligases) for Smac. cIAPs stimulate Smac ubiquitination both in vivo andin vitro …
mechanism by which IAPs prevent apoptosis has previously been attributed to the direct
inhibition of caspases. The function of mammalian IAPs is counteracted by cell death
inducer second mitochondria-derived activator of caspases (Smac)/DIABLO during
apoptosis. Here we show that cIAP1 and cIAP2 are E3 ubiquitin-protein isopeptide ligases
(ubiquitin ligases) for Smac. cIAPs stimulate Smac ubiquitination both in vivo andin vitro …