Ramipril administration to atherosclerotic mice reduces oxidized low-density lipoprotein uptake by their macrophages and blocks the progression of atherosclerosis
T Hayek, M Kaplan, A Raz, S Keidar, R Coleman… - Atherosclerosis, 2002 - Elsevier
Foam cell formation, the hallmark of early atherosclerosis, results from cholesterol
accumulation in arterial macrophages. Angiotensin-II stimulates foam cell formation and
angiotensin converting enzyme (ACE) inhibitors reduce atherosclerosis in animal models.
The goal of the present study was to determine the effect of the ACE inhibitor Ramipril on the
progression of atherosclerosis in apolipoprotein-E-deficient (E0) mice with already
advanced atherosclerosis. Therefore, 4-month-old atherosclerotic E0 mice were treated with …
accumulation in arterial macrophages. Angiotensin-II stimulates foam cell formation and
angiotensin converting enzyme (ACE) inhibitors reduce atherosclerosis in animal models.
The goal of the present study was to determine the effect of the ACE inhibitor Ramipril on the
progression of atherosclerosis in apolipoprotein-E-deficient (E0) mice with already
advanced atherosclerosis. Therefore, 4-month-old atherosclerotic E0 mice were treated with …
