Livers from mice lacking the carbohydrate-responsive element-binding protein (ChREBP)
were compared with wild type (WT) mice to determine the effect of this transcription factor on
hepatic energy metabolism. The pyruvate dehydrogenase complex was considerably more
active in ChREBP-/-mice because of diminished pyruvate dehydrogenase kinase activity.
Greater pyruvate dehydrogenase complex activity caused a stimulation of lactate and
pyruvate oxidation, and it significantly impaired fatty acid oxidation in perfused livers from …