[HTML][HTML] Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL …
XW Meng, SH Lee, H Dai, D Loegering, C Yu… - Journal of Biological …, 2007 - ASBMB
Previous studies have suggested that Mcl-1, an antiapoptotic Bcl-2 homolog that does not
exhibit appreciable affinity for the caspase 8-generated C-terminal Bid fragment (tBid),
diminishes sensitivity to tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL).
This study was performed to determine the mechanism by which Mcl-1 confers TRAIL
resistance and to evaluate methods for overcoming this resistance. Affinity purification/
immunoblotting assays using K562 human leukemia cells, which contain Mcl-1 and Bcl-x L …
exhibit appreciable affinity for the caspase 8-generated C-terminal Bid fragment (tBid),
diminishes sensitivity to tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL).
This study was performed to determine the mechanism by which Mcl-1 confers TRAIL
resistance and to evaluate methods for overcoming this resistance. Affinity purification/
immunoblotting assays using K562 human leukemia cells, which contain Mcl-1 and Bcl-x L …
