[HTML][HTML] Modulation of Cardiac Na+ Channel Expression in Xenopus Oocytes by β1 Subunits (∗)
Y Qu, LL Isom, RE Westenbroek, JC Rogers… - Journal of Biological …, 1995 - ASBMB
Voltage-gated Na+ channels consist of a large α subunit of 260 kDa associated with β1
and/or β2 subunits of 36 and 33 kDa, respectively. α subunits of rat cardiac Na+ channels
(rH1) are functional when expressed alone in Xenopus oocytes or mammalian cells. β1
subunits are present in the heart, and localization of β1 subunit mRNA by in situ
hybridization shows expression in the perinuclear cytoplasm of cardiac myocytes.
Coexpression of β1 subunits with rH1 α subunits in Xenopus oocytes increases Na+ …
and/or β2 subunits of 36 and 33 kDa, respectively. α subunits of rat cardiac Na+ channels
(rH1) are functional when expressed alone in Xenopus oocytes or mammalian cells. β1
subunits are present in the heart, and localization of β1 subunit mRNA by in situ
hybridization shows expression in the perinuclear cytoplasm of cardiac myocytes.
Coexpression of β1 subunits with rH1 α subunits in Xenopus oocytes increases Na+ …