Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract
A Sandilands, AR Prescott, A Wegener… - Experimental eye …, 2003 - Elsevier
In this report, the phenotype associated with the first targeted knockout of the lens specific
intermediate filament gene CP49 is described. Several surprising observations have been
made. The first was that no cataract was observed despite the fact that the beaded filaments
of the lens fibre cells had been disrupted. Light scatter and the lens optical properties had,
however, deteriorated in the CP49 knockout lenses compared to litter mate controls. These
changes were accompanied by dramatic changes in plasma membrane organisation of the …
intermediate filament gene CP49 is described. Several surprising observations have been
made. The first was that no cataract was observed despite the fact that the beaded filaments
of the lens fibre cells had been disrupted. Light scatter and the lens optical properties had,
however, deteriorated in the CP49 knockout lenses compared to litter mate controls. These
changes were accompanied by dramatic changes in plasma membrane organisation of the …
