Monogenic human obesity
IS Farooqi - Obesity and metabolism, 2008 - karger.com
Obesity and metabolism, 2008•karger.com
We and others have identified several single gene defects that disrupt the molecules in the
leptinmelanocortin pathway causing severe obesity in humans. In this review, we consider
these human monogenic obesity syndromes and discuss how far the characterisation of
these patients has informed our understanding of the physiological role of leptin and the
melanocortins in the regulation of human body weight and neuroendocrine function.
leptinmelanocortin pathway causing severe obesity in humans. In this review, we consider
these human monogenic obesity syndromes and discuss how far the characterisation of
these patients has informed our understanding of the physiological role of leptin and the
melanocortins in the regulation of human body weight and neuroendocrine function.
We and others have identified several single gene defects that disrupt the molecules in the leptinmelanocortin pathway causing severe obesity in humans. In this review, we consider these human monogenic obesity syndromes and discuss how far the characterisation of these patients has informed our understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function.
Karger