[PDF][PDF] Transcription factor FIGLA is mutated in patients with premature ovarian failure
The American Journal of Human Genetics, 2008•cell.com
Premature Ovarian Failure (POF) is a genetically heterogenous disorder that leads to
hypergonadotropic ovarian failure and infertility. We screened 100 Chinese women with
POF for mutations in the oocyte-specific gene FIGLA and identified three variants in four
women: missense mutation c. 11C→ A (p. A4E) was found in two women; deletion c. 15–36
del (p. G6fsX66), resulting in a frameshift that leads to haploinsufficiency, was found in one
woman; and deletion c. 419–421 delACA (p. 140 delN) was found in one. Functional …
hypergonadotropic ovarian failure and infertility. We screened 100 Chinese women with
POF for mutations in the oocyte-specific gene FIGLA and identified three variants in four
women: missense mutation c. 11C→ A (p. A4E) was found in two women; deletion c. 15–36
del (p. G6fsX66), resulting in a frameshift that leads to haploinsufficiency, was found in one
woman; and deletion c. 419–421 delACA (p. 140 delN) was found in one. Functional …
Premature Ovarian Failure (POF) is a genetically heterogenous disorder that leads to hypergonadotropic ovarian failure and infertility. We screened 100 Chinese women with POF for mutations in the oocyte-specific gene FIGLA and identified three variants in four women: missense mutation c.11C → A (p.A4E) was found in two women; deletion c. 15–36 del (p.G6fsX66), resulting in a frameshift that leads to haploinsufficiency, was found in one woman; and deletion c.419–421 delACA (p.140 delN) was found in one. Functional analyses by the yeast two-hybrid assay demonstrated that the p.140 delN mutation disrupted FIGLA binding to the TCF3 helix-loop-helix (HLH) domain. Our findings show that a subset of Chinese women with sporadic, premature ovarian failure harbor mutations in FIGLA.
cell.com