[HTML][HTML] TLR8-mediated NF-κB and JNK activation are TAK1-independent and MEKK3-dependent
J Qin, J Yao, G Cui, H Xiao, TW Kim, J Fraczek… - Journal of Biological …, 2006 - ASBMB
TLR8-mediated NF-κB and IRF7 activation are abolished in human IRAK-deficient 293 cells
and IRAK4-deficient fibroblast cells. Both wild-type and kinase-inactive mutants of IRAK and
IRAK4, respectively, restored TLR8-mediated NF-κB and IRF7 activation in the IRAK-and
IRAK4-deficient cells, indicating that the kinase activity of IRAK and IRAK4 is probably
redundant for TLR8-mediated signaling. We recently found that TLR8 mediates a unique NF-
κB activation pathway in human 293 cells and mouse embryonic fibroblasts, accompanied …
and IRAK4-deficient fibroblast cells. Both wild-type and kinase-inactive mutants of IRAK and
IRAK4, respectively, restored TLR8-mediated NF-κB and IRF7 activation in the IRAK-and
IRAK4-deficient cells, indicating that the kinase activity of IRAK and IRAK4 is probably
redundant for TLR8-mediated signaling. We recently found that TLR8 mediates a unique NF-
κB activation pathway in human 293 cells and mouse embryonic fibroblasts, accompanied …