SPG3A is the most frequent cause of hereditary spastic paraplegia with onset before age 10 years
M Namekawa, P Ribai, I Nelson, S Forlani, F Fellmann… - Neurology, 2006 - AAN Enterprises
M Namekawa, P Ribai, I Nelson, S Forlani, F Fellmann, C Goizet, C Depienne, G Stevanin…
Neurology, 2006•AAN EnterprisesSeven families with six different SPG3A mutations were identified among 106 with
autosomal dominant hereditary spastic paraplegia (HSP). Two mutations were novel
(T162P, C375R). SPG3A was twice as frequent as SPG4 in patients with onset before age
10 years (31.8%). Later onset was not observed. The phenotype was pure HSP, but disease
duration was longer than in non-SPG3A/SPG4 patients, leading ultimately to greater
handicap.
autosomal dominant hereditary spastic paraplegia (HSP). Two mutations were novel
(T162P, C375R). SPG3A was twice as frequent as SPG4 in patients with onset before age
10 years (31.8%). Later onset was not observed. The phenotype was pure HSP, but disease
duration was longer than in non-SPG3A/SPG4 patients, leading ultimately to greater
handicap.
Seven families with six different SPG3A mutations were identified among 106 with autosomal dominant hereditary spastic paraplegia (HSP). Two mutations were novel (T162P, C375R). SPG3A was twice as frequent as SPG4 in patients with onset before age 10 years (31.8%). Later onset was not observed. The phenotype was pure HSP, but disease duration was longer than in non-SPG3A/SPG4 patients, leading ultimately to greater handicap.
American Academy of Neurology