[HTML][HTML] Four stages and lack of stable accommodation in chronic alloantibody-mediated renal allograft rejection in Cynomolgus monkeys
RN Smith, T Kawai, S Boskovic, O Nadazdin… - American Journal of …, 2008 - Elsevier
The etiology of immunologically mediated chronic renal allograft failure is unclear. One
cause is thought to be alloantibodies. Previously in Cynomolgus monkeys, we observed a
relationship among donor-specific alloantibodies (DSA), C4d staining, allograft
glomerulopathy, allograft arteriopathy and progressive renal failure. To define the natural
history of chronic antibody-mediated rejection and its effect on renal allograft survival, we
now extend this report to include 417 specimens from 143 Cynomolgus monkeys with renal …
cause is thought to be alloantibodies. Previously in Cynomolgus monkeys, we observed a
relationship among donor-specific alloantibodies (DSA), C4d staining, allograft
glomerulopathy, allograft arteriopathy and progressive renal failure. To define the natural
history of chronic antibody-mediated rejection and its effect on renal allograft survival, we
now extend this report to include 417 specimens from 143 Cynomolgus monkeys with renal …