Identification of a cDNA for Ca++-independent phospholipase A2 of lung lamellar bodies/lysosomes
AB Fisher, SI Feinstein, TS Kim, C Dodia, W Skach - Chest, 1997 - journal.chestnet.org
T o many investigators, the concept of gene therapy involves the permanent transfer of a
normal gene to the genome of an individual to replace a nonfunctioning (mutated) gene with
reversal or prevention of the onset of the disease process. Just as valid would be the
temporary introduction of a normal gene to tissues without genomic integration, resulting in
transient gene expression and production of the functional gene product to modify tissue
responses or provide temporary protection from pathogenic mechanisms. Such a concept …
normal gene to the genome of an individual to replace a nonfunctioning (mutated) gene with
reversal or prevention of the onset of the disease process. Just as valid would be the
temporary introduction of a normal gene to tissues without genomic integration, resulting in
transient gene expression and production of the functional gene product to modify tissue
responses or provide temporary protection from pathogenic mechanisms. Such a concept …