Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein …
F Syeda, J Grosjean, RA Houliston, RJ Keogh… - Journal of Biological …, 2006 - ASBMB
The functional significance of protease-activated receptors (PARs) in endothelial cells is
largely undefined, and the intracellular consequences of their activation are poorly
understood. Here, we show that the serine protease thrombin, a PAR-1-selective peptide
(TFLLRN), and SLIGKV (PAR-2-selective peptide) induce cyclooxygenase-2 (COX-2)
protein and mRNA expression in human endothelial cells without modifying COX-1
expression. COX-2 induction was accompanied by sustained production of 6-keto-PGF 1α …
largely undefined, and the intracellular consequences of their activation are poorly
understood. Here, we show that the serine protease thrombin, a PAR-1-selective peptide
(TFLLRN), and SLIGKV (PAR-2-selective peptide) induce cyclooxygenase-2 (COX-2)
protein and mRNA expression in human endothelial cells without modifying COX-1
expression. COX-2 induction was accompanied by sustained production of 6-keto-PGF 1α …
