[HTML][HTML] Rab27a: a new face in β cell metabolism-secretion coupling
T Aizawa, M Komatsu - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
T Aizawa, M Komatsu
The Journal of clinical investigation, 2005•Am Soc Clin InvestigIn pancreatic β cells, not only insulin exocytosis per se, but translocation of β granules
toward the plasma membrane—an event upstream of exocytosis—are under the control of
glucose. However, the molecular basis of this translocation has been poorly understood.
Rab27a-mediated translocation of glucose-induced β granules is reported in this issue of
the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target
because potentiation of the Rab27a pathway is expected to restore β cell glucose …
toward the plasma membrane—an event upstream of exocytosis—are under the control of
glucose. However, the molecular basis of this translocation has been poorly understood.
Rab27a-mediated translocation of glucose-induced β granules is reported in this issue of
the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target
because potentiation of the Rab27a pathway is expected to restore β cell glucose …
In pancreatic β cells, not only insulin exocytosis per se, but translocation of β granules toward the plasma membrane — an event upstream of exocytosis — are under the control of glucose. However, the molecular basis of this translocation has been poorly understood. Rab27a-mediated translocation of glucose-induced β granules is reported in this issue of the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target because potentiation of the Rab27a pathway is expected to restore β cell glucose competency in patients with diabetes mellitus.
The Journal of Clinical Investigation