Objective: To compare the safety and efficacy of earlier vs later treatment in preventing
primary openangle glaucoma (POAG) in individuals with ocular hypertension. Methods: One
thousand six hundred thirty-six individuals with intraocular pressure (IOP) from 24 to 32 mm
Hg in 1 eye and 21 to 32 mm Hg in the fellow eye were randomized to observation or to
topical ocular hypotensive medication. Median time of treatment in the medication group
was 13.0 years. After a median of 7.5 years without treatment, the observation group …