Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?
MI Koenders, WB Van Den Berg - Clinical & Experimental …, 2010 - academic.oup.com
MI Koenders, WB Van Den Berg
Clinical & Experimental Immunology, 2010•academic.oup.comAbstract OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON Th17 CELLS
Function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol
2009; doi: 10.1111/j. 1365-2249.2009. 04037. x Induction of interleukin-17 production by
regulatory T cells. Clin Exp Immunol 2009; doi: 10.1111/j. 1365-2249.2009. 04038. x CD4+
T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated
regulation. Clin Exp Immunol 2009; doi: 10.1111/j. 1365-2249.2009. 04040. x Development …
Function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol
2009; doi: 10.1111/j. 1365-2249.2009. 04037. x Induction of interleukin-17 production by
regulatory T cells. Clin Exp Immunol 2009; doi: 10.1111/j. 1365-2249.2009. 04038. x CD4+
T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated
regulation. Clin Exp Immunol 2009; doi: 10.1111/j. 1365-2249.2009. 04040. x Development …
Abstract
OTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON Th17 CELLS
Function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 2009; doi:10.1111/j.1365-2249.2009.04037.x
Induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol 2009; doi:10.1111/j.1365-2249.2009.04038.x
CD4+ T helper cells: functional plasticity and differential sensitivity to regulatory T cell-mediated regulation. Clin Exp Immunol 2009; doi:10.1111/j.1365-2249.2009.04040.x
Development of mouse and human T helper 17 cells. Clin Exp Immunol 2009; doi:10.1111/j.1365-2249.2009.04041.x
Summary
In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.
Oxford University Press