[HTML][HTML] Cloning of a cholesterol-α-glucosyltransferase from Helicobacter pylori
AH Lebrun, C Wunder, J Hildebrand, Y Churin… - Journal of Biological …, 2006 - ASBMB
O-Glycans of the human gastric mucosa show antimicrobial activity against the pathogenic
bacterium Helicobacter pylori by inhibiting the bacterial cholesterol-α-glucosyltransferase
(Kawakubo, M., Ito, Y., Okimura, Y., Kobayashi, M., Sakura, K., Kasama, S., Fukuda, MN,
Fukuda, M., Katsuyama, T., and Nakayama, J.(2004) Science 305, 1003–1006). This
enzyme catalyzes the first step in the biosynthesis of four unusual glycolipids: cholesteryl-α-
glucoside, cholesteryl-6′-O-acyl-α-glucoside, cholesteryl-6′-O-phosphatidyl-α-glucoside …
bacterium Helicobacter pylori by inhibiting the bacterial cholesterol-α-glucosyltransferase
(Kawakubo, M., Ito, Y., Okimura, Y., Kobayashi, M., Sakura, K., Kasama, S., Fukuda, MN,
Fukuda, M., Katsuyama, T., and Nakayama, J.(2004) Science 305, 1003–1006). This
enzyme catalyzes the first step in the biosynthesis of four unusual glycolipids: cholesteryl-α-
glucoside, cholesteryl-6′-O-acyl-α-glucoside, cholesteryl-6′-O-phosphatidyl-α-glucoside …