Immunostimulatory and antitumor activities of monoglycosylceramides having various sugar moieties
K Motoki, M MORITA, E KOBAYASHI… - Biological and …, 1995 - jstage.jst.go.jp
K Motoki, M MORITA, E KOBAYASHI, T UCHIDA, K AKIMOTO, H FUKUSHIMA, Y KOEZUKA
Biological and Pharmaceutical Bulletin, 1995•jstage.jst.go.jp抄録 Ten kinds of monoglycosylceramides (MonoCers), having the same ceramide portion
and different sugar moieties, were synthesized and their immunostimulatory and antitumor
activities were examined. The manner of combination between sugar and ceramide has
been demonstrated to affect the manifestation of immunostimulatory and resultant antitumor
activities of MonoCers, and in the case of D-MonoCers having the D-sugar, α-D-MonoCers
(sugar combined to ceramide in an α-configuration) show stronger activities than β-D …
and different sugar moieties, were synthesized and their immunostimulatory and antitumor
activities were examined. The manner of combination between sugar and ceramide has
been demonstrated to affect the manifestation of immunostimulatory and resultant antitumor
activities of MonoCers, and in the case of D-MonoCers having the D-sugar, α-D-MonoCers
(sugar combined to ceramide in an α-configuration) show stronger activities than β-D …
抄録
Ten kinds of monoglycosylceramides (MonoCers), having the same ceramide portion and different sugar moieties, were synthesized and their immunostimulatory and antitumor activities were examined. The manner of combination between sugar and ceramide has been demonstrated to affect the manifestation of immunostimulatory and resultant antitumor activities of MonoCers, and in the case of D-MonoCers having the D-sugar, α-D-MonoCers (sugar combined to ceramide in an α-configuration) show stronger activities than β-D-MonoCers. Furthermore, the form of sugar, not the furanose-form but the pyranose-form, and the 2''-and 4''-hydroxyl groups of the pyranose-form of sugar, seemed to play an important role in the manifestation of the activities of α-D-MonoCers.
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