[HTML][HTML] Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor
S Dhanvantari, YP Loh - Journal of Biological Chemistry, 2000 - ASBMB
Membrane carboxypeptidase E (CPE) is a sorting receptor for targeting prohormones, such
as pro-opiomelanocortin, to the regulated secretory pathway in endocrine cells. Its
membrane association is necessary for it to bind a prohormone sorting signal at the trans-
Golgi network (TGN) to facilitate targeting. In this study, we examined the lipid interaction of
CPE in bovine pituitary secretory granule membranes, which are derived from the TGN. We
show that CPE is associated with detergent-resistant lipid domains, or rafts, within secretory …
as pro-opiomelanocortin, to the regulated secretory pathway in endocrine cells. Its
membrane association is necessary for it to bind a prohormone sorting signal at the trans-
Golgi network (TGN) to facilitate targeting. In this study, we examined the lipid interaction of
CPE in bovine pituitary secretory granule membranes, which are derived from the TGN. We
show that CPE is associated with detergent-resistant lipid domains, or rafts, within secretory …