Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
SH Ganji, S Qin, L Zhang, VS Kamanna, ML Kashyap - Atherosclerosis, 2009 - Elsevier
In pharmacological doses, nicotinic acid (niacin) reduces myocardial infarction, stroke and
atherosclerosis. The beneficial effects of niacin on lipoproteins are thought to mediate these
effects. We hypothesized that niacin inhibits oxidative stress and redox-sensitive
inflammatory genes that play a critical role in early atherogenesis. In cultured human aortic
endothelial cells (HAEC), niacin increased nicotinamide adenine dinucleotide phosphate
(NAD (P) H) levels by 54% and reduced glutathione (GSH) by 98%. Niacin inhibited:(a) …
atherosclerosis. The beneficial effects of niacin on lipoproteins are thought to mediate these
effects. We hypothesized that niacin inhibits oxidative stress and redox-sensitive
inflammatory genes that play a critical role in early atherogenesis. In cultured human aortic
endothelial cells (HAEC), niacin increased nicotinamide adenine dinucleotide phosphate
(NAD (P) H) levels by 54% and reduced glutathione (GSH) by 98%. Niacin inhibited:(a) …