The Cholesterol Lowering Atherosclerosis Study (CLAS): design, methods, and baseline results
DH Blankenhorn, RL Johnson, SA Nessim… - Controlled Clinical …, 1987 - Elsevier
Abstract The Cholesterol Lowering Atherosclerosis Study (CLAS) is a prospective, placebo-
controlled, angiographic trial designed to test the hypothesis that aggressive lowering of
LDL cholesterol with concomitant increase in HDL cholesterol will reverse or retard the
atherosclerotic process. Specifically, CLAS was designed to determine whether combined
therapy with colestipol plus niacin will produce clinically significant change in coronary,
carotid, and femoral artery atherosclerosis and coronary bypass graft lesions. To this …
controlled, angiographic trial designed to test the hypothesis that aggressive lowering of
LDL cholesterol with concomitant increase in HDL cholesterol will reverse or retard the
atherosclerotic process. Specifically, CLAS was designed to determine whether combined
therapy with colestipol plus niacin will produce clinically significant change in coronary,
carotid, and femoral artery atherosclerosis and coronary bypass graft lesions. To this …
