[HTML][HTML] PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation
Mitosis is an orchestration of dynamic interactions between spindle microtubules and
chromosomes, which is mediated by protein structures that include the kinetochores, and
other protein complexes present on chromosomes. PinX1 is a potent telomerase inhibitor in
interphase; however, its function in mitosis is not well documented. Here we show that PinX1
is essential for faithful chromosome segregation. Deconvolution microscopic analyses show
that PinX1 localizes to nucleoli and telomeres in interphase and relocates to the periphery of …
chromosomes, which is mediated by protein structures that include the kinetochores, and
other protein complexes present on chromosomes. PinX1 is a potent telomerase inhibitor in
interphase; however, its function in mitosis is not well documented. Here we show that PinX1
is essential for faithful chromosome segregation. Deconvolution microscopic analyses show
that PinX1 localizes to nucleoli and telomeres in interphase and relocates to the periphery of …