[HTML][HTML] PUMA dissociates Bax and BCL-XL to induce apoptosis in colon cancer cells
PUMA is a BH3-only Bcl-2 family protein that plays an essential role in DNA damage-
induced apoptosis. PUMA interacts with anti-apoptotic Bcl-2 and Bcl-X L and is dependent
on Bax to induce apoptosis. In this study, we investigated how the interactions of PUMA with
the antiapoptotic proteins coordinate with Bax to initiate apoptosis in HCT116 colon cancer
cells. We found that Bcl-X L was most effective among several antiapoptotic proteins in
suppressing PUMA-induced apoptosis and PUMA-dependent apoptosis induced by the …
induced apoptosis. PUMA interacts with anti-apoptotic Bcl-2 and Bcl-X L and is dependent
on Bax to induce apoptosis. In this study, we investigated how the interactions of PUMA with
the antiapoptotic proteins coordinate with Bax to initiate apoptosis in HCT116 colon cancer
cells. We found that Bcl-X L was most effective among several antiapoptotic proteins in
suppressing PUMA-induced apoptosis and PUMA-dependent apoptosis induced by the …