[HTML][HTML] Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice
GATA5 is a member of the zinc finger transcription factor GATA family (GATA1–6) that plays
a wide variety of roles in embryonic and adult development. Experiments in multiple model
systems have emphasized the importance of the GATA family members 4–6 in the
development of the endoderm and mesoderm. Yet despite overlapping expression patterns,
there is little evidence of an important role for GATA5 in mammalian cardiac development.
We have generated a new Gata5 mutant allele lacking exons 2 and 3 that encodes both zinc …
a wide variety of roles in embryonic and adult development. Experiments in multiple model
systems have emphasized the importance of the GATA family members 4–6 in the
development of the endoderm and mesoderm. Yet despite overlapping expression patterns,
there is little evidence of an important role for GATA5 in mammalian cardiac development.
We have generated a new Gata5 mutant allele lacking exons 2 and 3 that encodes both zinc …