[HTML][HTML] Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin …
S Suetsugu, H Miki, T Takenawa - Journal of Biological Chemistry, 2001 - ASBMB
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an essential regulator of actin
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It
is believed that the C-terminal Arp2/3 complex-activating domain (verprolin homology, cofilin
homology, andacidic (VCA) or C-terminal region of WASP family proteins domain) of N-
WASP is usually kept masked (autoinhibition) but is opened upon cooperative binding of
upstream regulators such as Cdc42 and phosphatidylinositol 4, 5-bisphosphate (PIP2) …
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It
is believed that the C-terminal Arp2/3 complex-activating domain (verprolin homology, cofilin
homology, andacidic (VCA) or C-terminal region of WASP family proteins domain) of N-
WASP is usually kept masked (autoinhibition) but is opened upon cooperative binding of
upstream regulators such as Cdc42 and phosphatidylinositol 4, 5-bisphosphate (PIP2) …