Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
DE Shaw, MA Berry, B Hargadon, S McKenna… - Chest, 2007 - Elsevier
Background There is debate about the mechanisms of persistent airflow limitation in patients
with asthma. Chronic inflammation is assumed to be important, although there is limited and
contradictory information about the relationship between airway inflammation and
postbronchodilator FEV 1. Methods We have assessed the cross-sectional relationship
between prebronchodilator and postbronchodilator FEV 1 and measures of airway
inflammation after allowing for the effects of potential confounding factors. Multivariate …
with asthma. Chronic inflammation is assumed to be important, although there is limited and
contradictory information about the relationship between airway inflammation and
postbronchodilator FEV 1. Methods We have assessed the cross-sectional relationship
between prebronchodilator and postbronchodilator FEV 1 and measures of airway
inflammation after allowing for the effects of potential confounding factors. Multivariate …