[HTML][HTML] Natural soluble interleukin-15Rα is generated by cleavage that involves the tumor necrosis factor-α-converting enzyme (TACE/ADAM17)
V Budagian, E Bulanova, Z Orinska, A Ludwig… - Journal of Biological …, 2004 - ASBMB
This study shows that the high affinity α-chain of the interleukin (IL)-15 receptor exists not
only in membrane-anchored but also in soluble form. Soluble IL-15Rα (sIL-15Rα) can be
detected in mouse sera and cell-conditioned media by enzyme-linked immunosorbent assay
and by immunoprecipitation and Western blotting. This protein has a molecular mass of
about 30 kDa because of the presence of a single N-glycosylation site, which is reduced to
26 kDa after N-glycosidase treatment. Transmembrane IL-15Rα is constitutively converted …
only in membrane-anchored but also in soluble form. Soluble IL-15Rα (sIL-15Rα) can be
detected in mouse sera and cell-conditioned media by enzyme-linked immunosorbent assay
and by immunoprecipitation and Western blotting. This protein has a molecular mass of
about 30 kDa because of the presence of a single N-glycosylation site, which is reduced to
26 kDa after N-glycosidase treatment. Transmembrane IL-15Rα is constitutively converted …