[HTML][HTML] p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells
Y Liu, C Wu, K Galaktionov - Journal of Biological Chemistry, 2004 - ASBMB
The cyclin-dependent kinase (CDK)-activating kinase (CAK) phosphorylates a conserved
threonine residue on CDKs and activates them. Two known classes of CAKs are
represented by monomeric Cak1p in budding yeast Saccharomyces cerevisiae and by
heterotrimeric CDK7-cyclin H-Mat1 in human and other metazoa. We report here the
identification of p42, a novel CAK activity in human cells. p42 has sequence homology to
both Cak1p and CDK7 groups of CAKs. p42 is essential for the phosphorylation of Thr-160 …
threonine residue on CDKs and activates them. Two known classes of CAKs are
represented by monomeric Cak1p in budding yeast Saccharomyces cerevisiae and by
heterotrimeric CDK7-cyclin H-Mat1 in human and other metazoa. We report here the
identification of p42, a novel CAK activity in human cells. p42 has sequence homology to
both Cak1p and CDK7 groups of CAKs. p42 is essential for the phosphorylation of Thr-160 …