Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation

C Mayr, MT Hemann, DP Bartel - Science, 2007 - science.org
C Mayr, MT Hemann, DP Bartel
Science, 2007science.org
MicroRNAs (miRNAs) are∼ 22-nucleotide RNAs that can pair to sites within messenger
RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA
expression can contribute to tumorigenesis, but which of the many miRNA-target
relationships are relevant to this process has been unclear. Here, we report that
chromosomal translocations previously associated with human tumors disrupt repression of
High Mobility Group A2 (Hmga2) by let-7 miRNA. This disrupted repression promotes …
MicroRNAs (miRNAs) are ∼22-nucleotide RNAs that can pair to sites within messenger RNAs to specify posttranscriptional repression of these messages. Aberrant miRNA expression can contribute to tumorigenesis, but which of the many miRNA-target relationships are relevant to this process has been unclear. Here, we report that chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA. This disrupted repression promotes anchorage-independent growth, a characteristic of oncogenic transformation. Thus, losing miRNA-directed repression of an oncogene provides a mechanism for tumorigenesis, and disrupting a single miRNA-target interaction can produce an observable phenotype in mammalian cells.
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