[HTML][HTML] CD36 protein is involved in store-operated calcium flux, phospholipase A2 activation, and production of prostaglandin E2
O Kuda, CM Jenkins, JR Skinner, SH Moon… - Journal of Biological …, 2011 - ASBMB
The scavenger receptor FAT/CD36 contributes to the inflammation associated with diabetes,
atherosclerosis, thrombosis, and Alzheimer disease. Underlying mechanisms include CD36
promotion of oxidative stress and its signaling to stress kinases. Here we document an
additional mechanism for the role of CD36 in inflammation. CD36 regulates membrane
calcium influx in response to endoplasmic reticulum (ER) stress, release of arachidonic acid
(AA) from cellular membranes by cytoplasmic phospholipase A 2 α (cPLA 2 α) and …
atherosclerosis, thrombosis, and Alzheimer disease. Underlying mechanisms include CD36
promotion of oxidative stress and its signaling to stress kinases. Here we document an
additional mechanism for the role of CD36 in inflammation. CD36 regulates membrane
calcium influx in response to endoplasmic reticulum (ER) stress, release of arachidonic acid
(AA) from cellular membranes by cytoplasmic phospholipase A 2 α (cPLA 2 α) and …