[HTML][HTML] P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells
I Oruetxebarria, F Venturini, T Kekarainen… - Journal of Biological …, 2004 - ASBMB
The hSNF5 chromatin-remodeling factor is a tumor suppressor that is inactivated in
malignant rhabdoid tumors (MRTs). A number of studies have shown that hSNF5 re-
expression blocks MRT cell proliferation. However, the pathway through which hSNF5 acts
remains unknown. To address this question, we generated MRT-derived cell lines in which
restoration of hSNF5 expression leads to an accumulation in G 0/G 1, induces cellular
senescence and increased apoptosis. Following hSNF5 expression, we observed …
malignant rhabdoid tumors (MRTs). A number of studies have shown that hSNF5 re-
expression blocks MRT cell proliferation. However, the pathway through which hSNF5 acts
remains unknown. To address this question, we generated MRT-derived cell lines in which
restoration of hSNF5 expression leads to an accumulation in G 0/G 1, induces cellular
senescence and increased apoptosis. Following hSNF5 expression, we observed …