Aldose reductase: congenial and injurious profiles of an enigmatic enzyme
A Bhatnagar, SK Srivastava - Biochemical medicine and metabolic biology, 1992 - Elsevier
Cellular utilization of glucose is initiated by hexokinase-catalyzed phosphorylation of
glucose to glucose 6-phosphate. Phosphorylated glucose enters the glycolytic pathway, the
hexose monophosphate shunt, or is utilized for biosynthesis of amino-sugars and
nucleosides. In addition, nonphosphorylated glucose is metabolized in most cells via an
accessory pathway of glucose metabolism known as the polyol pathway. The rate-limiting
step in the polyol pathway is the aldose reductase-catalyzed reduction of glucose to sorbitol …
glucose to glucose 6-phosphate. Phosphorylated glucose enters the glycolytic pathway, the
hexose monophosphate shunt, or is utilized for biosynthesis of amino-sugars and
nucleosides. In addition, nonphosphorylated glucose is metabolized in most cells via an
accessory pathway of glucose metabolism known as the polyol pathway. The rate-limiting
step in the polyol pathway is the aldose reductase-catalyzed reduction of glucose to sorbitol …