Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines
D Guo, J Ye, J Dai, L Li, F Chen, D Ma, C Ji - Leukemia research, 2009 - Elsevier
Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL),
making this receptor a promising target for drugs such as gamma-secretase inhibitors
(GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with
constitutive Notch-1 activity and the downstream response of Notch signaling is only partially
understood. To further investigate the molecular mechanisms underlying proliferation
suppression and apoptosis and explore effective downstream target genes, we used RNA …
making this receptor a promising target for drugs such as gamma-secretase inhibitors
(GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with
constitutive Notch-1 activity and the downstream response of Notch signaling is only partially
understood. To further investigate the molecular mechanisms underlying proliferation
suppression and apoptosis and explore effective downstream target genes, we used RNA …