[HTML][HTML] Glucose suppression of glucagon secretion: metabolic and calcium responses from α-cells in intact mouse pancreatic islets
SJ Le Marchand, DW Piston - Journal of Biological Chemistry, 2010 - ASBMB
Glucagon is released from α-cells present in intact pancreatic islets at glucose
concentrations below 4 mm, whereas higher glucose levels inhibit its secretion. The
mechanisms underlying the suppression of α-cell secretory activity are poorly understood,
but two general types of models have been proposed as follows: direct inhibition by glucose
or paracrine inhibition from non-α-cells within the islet of Langerhans. To identify α-cells for
analysis, we utilized transgenic mice expressing fluorescent proteins targeted specifically to …
concentrations below 4 mm, whereas higher glucose levels inhibit its secretion. The
mechanisms underlying the suppression of α-cell secretory activity are poorly understood,
but two general types of models have been proposed as follows: direct inhibition by glucose
or paracrine inhibition from non-α-cells within the islet of Langerhans. To identify α-cells for
analysis, we utilized transgenic mice expressing fluorescent proteins targeted specifically to …