[HTML][HTML] Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis
KK Dutta, Y Nishinaka, H Masutani, S Akatsuka… - Laboratory …, 2005 - Elsevier
Thioredoxin is a major component of thiol-reducing system. Recently, we identified
thioredoxin-binding protein-2 (TBP-2) as a negative regulator of thioredoxin. Here, we report
the role of TBP-2 in oxidative renal tubular injury and the subsequent carcinogenesis by
ferric nitrilotriacetate. TBP-2 was abundantly expressed in the rat kidney.
Immunohistochemical analysis revealed that TBP-2 was present in association with nuclei
and mitochondrial intermembrane space in the proximal tubular cells and …
thioredoxin-binding protein-2 (TBP-2) as a negative regulator of thioredoxin. Here, we report
the role of TBP-2 in oxidative renal tubular injury and the subsequent carcinogenesis by
ferric nitrilotriacetate. TBP-2 was abundantly expressed in the rat kidney.
Immunohistochemical analysis revealed that TBP-2 was present in association with nuclei
and mitochondrial intermembrane space in the proximal tubular cells and …
