Intra-arterial and oral digoxin therapy for retinoblastoma
Ophthalmic Genetics, 2011•Taylor & Francis
Purpose: Preclinical studies demonstrate that cardiac glycosides such as ouabain and
digoxin have antitumor effects on retinoblastoma cells in vitro and in a xenograft murine
model of retinoblastoma. Methods: Based on these findings, we report a case of intra-arterial
followed by systemic oral digoxin therapy in a patient with unilateral retinoblastoma that had
failed prior intra-arterial chemotherapy. Results: Oral administration of digoxin produced no
effect, while intra-arterial digoxin therapy produced a modest but measurable response that …
digoxin have antitumor effects on retinoblastoma cells in vitro and in a xenograft murine
model of retinoblastoma. Methods: Based on these findings, we report a case of intra-arterial
followed by systemic oral digoxin therapy in a patient with unilateral retinoblastoma that had
failed prior intra-arterial chemotherapy. Results: Oral administration of digoxin produced no
effect, while intra-arterial digoxin therapy produced a modest but measurable response that …
Purpose: Preclinical studies demonstrate that cardiac glycosides such as ouabain and digoxin have antitumor effects on retinoblastoma cells in vitro and in a xenograft murine model of retinoblastoma.
Methods: Based on these findings, we report a case of intra-arterial followed by systemic oral digoxin therapy in a patient with unilateral retinoblastoma that had failed prior intra-arterial chemotherapy.
Results: Oral administration of digoxin produced no effect, while intra-arterial digoxin therapy produced a modest but measurable response that was likely limited by the inability to achieve sustained drug concentration in the eye.
Conclusions: This case highlights both the potential promise and limitations of cardiac glycoside therapy in retinoblastoma.
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