Preconditioning and adenosine protect human proximal tubule cells in an in vitro model of ischemic injury
HT Lee, CW Emala - Journal of the American Society of …, 2002 - journals.lww.com
Renal ischemic reperfusion injury results in unacceptably high mortality and morbidity
during the perioperative period. It has been recently demonstrated that ischemic
preconditioning or adenosine receptor modulations attenuate renal ischemic reperfusion
injury in vivo. An in vitro model of ischemic renal injury was used in cultured human proximal
tubule (HK-2) cells to further elucidate the protective signaling cascades against renal
ischemic reperfusion injury. ATP depletion preconditioning (1 h of antimycin A and 2 …
during the perioperative period. It has been recently demonstrated that ischemic
preconditioning or adenosine receptor modulations attenuate renal ischemic reperfusion
injury in vivo. An in vitro model of ischemic renal injury was used in cultured human proximal
tubule (HK-2) cells to further elucidate the protective signaling cascades against renal
ischemic reperfusion injury. ATP depletion preconditioning (1 h of antimycin A and 2 …