That adenosine signaling can elicit adaptive tissue responses during conditions of limited
oxygen availability (hypoxia) is a long-suspected notion that recently gained general
acceptance from genetic and pharmacologic studies of the adenosine signaling pathway. As
hypoxia and inflammation share an interdependent relationship, these studies have
demonstrated that adenosine signaling events can be targeted to dampen hypoxia-induced
inflammation. Here, we build on the hypothesis that particularly the A 2B adenosine receptor …