Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury
P Hill, D Shukla, MGB Tran, J Aragones… - Journal of the …, 2008 - journals.lww.com
Acute renal failure resulting from hypoperfusion and hypoxia is a significant clinical problem.
Hypoxia activates the heterodimeric transcription factor hypoxia inducible factor (HIF),
leading to changes in gene expression that promote tissue adaptation and survival. To
determine whether HIF may protect the kidney from ischemia-reperfusion injury, we
subjected hif1a+/− and hif2a+/− mice to renal ischemia-reperfusion injury. Injury was
substantially more severe in hif+/− than in littermate controls, consistent with a protective role …
Hypoxia activates the heterodimeric transcription factor hypoxia inducible factor (HIF),
leading to changes in gene expression that promote tissue adaptation and survival. To
determine whether HIF may protect the kidney from ischemia-reperfusion injury, we
subjected hif1a+/− and hif2a+/− mice to renal ischemia-reperfusion injury. Injury was
substantially more severe in hif+/− than in littermate controls, consistent with a protective role …